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The conversation about GLP-1 drugs has been focused on hunger
(2017) Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life Rubino, Francesco, et al
Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site
In vitro studies have shown that liraglutide intervention can dose-dependently increase the expression of insulin signaling pathway-related proteins such as GLUT-4 and p-Akt after the induction of IR in L6 muscle cells in a high lipid environment simulated by palmitic acid (PA), thus effectively improving the insulin sensitivity of L6 cells [18]
GLP-1 medications have shown benefits for weight loss and improving insulin sensitivity in women with PCOS, although treatment should always be individualised
This means that addressing untreated insulin resistance could potentially support milk production in some individuals by improving the bodys response to prolactin
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