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In putamen, GPX4 was concentrated within dystrophic dopaminergic axons in Parkinson's subjects, although overall levels of GPX4 were not significantly different compared to control putamen
Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide
Its major role is as an antioxidant (1) , involved in the elimination of free radicals and the detoxification of the liver through liver glutathione
Front Immunol 12:628168
Why is it described as highly active at low concentrations
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