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Jin et al

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one way to quantify this is the waist-to-height ratio Waist-to-height is more effective than BMI at predicting the risk of certain diseases, especially CVD A ratio of 0.400.49 is normal, 0.500.59 is increased risk, and the highest risk is 0.60 Even at normal BMI, people with a larger waist-to-height are at greater risk of CVD and complications Knowing this may help to identify at-risk individuals in clinical practice Waist-to-height ratio is a better predictor of the presence or absence of cardiovascular disease than BMI, which really doesnt predict it. - Louis Aronne One of the good things about SELECT was the 4 years of observation in a really diverse, large population. - Donna Ryan Long-term Effects of Semaglutide Key takeaways SELECT provides 4 years of observation in a diverse population of over 17,000 people These additional long-term safety and efficacy data support the known profile of semaglutide and the wider GLP-1RA class Tolerability is well known, and there are steps that can be taken in clinical practice to manage common GI side effects With no new safety signals, SELECT reinforces this and helps to build confidence in using this class in everyday practice SELECT CVD Outcomes and Obesity Key takeaways The CV benefits seen with semaglutide may transform patient care and obesity management Even in people at very high CV risk, semaglutide may reduce heart attack, stroke, and CV death as seen in the SELECT trial There are multiple CV benefits, including improvement in heart failure and CKD, and this may result in a broadening of indications for semaglutide But semaglutide is already an option for secondary prevention of CVD, and this is translating into payer willingness to fund Results also suggest semaglutide is a powerful anti-inflammatory drug Its not just about heart attack and stroke

Clinical effects of GLP 1 receptor agonists and dual incretin agonists

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