Gupta emphasizes that weight regain is common after discontinuing the medication, making it clear that GLP-1s should not be seen as a quick fix. These medications are a valuable tool, but they work best when combined with other strategies, he notes
they can also improve metabolic health by lowering inflammation in the body and boosting weight loss, which can make it easier to manage the condition
Cardiovascular outcome trials have demonstrated reductions in major adverse cardiovascular events in high-risk patients, prompting investigation into their effects on various cardiovascular risk factors, including lipid profiles
"The most commonly reported side effects are GI-related: nausea, constipation, loose stools, vomiting," Lofton said
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In the Veterans Health Administration (VHA) national dataset, an adjusted OR indicated no significant difference in pancreatitis occurrences between thiazolidinedione and incretin groups (adjusted OR, 0.94