The FDA has specifically evaluated it as a bulk drug substance for compounding and raised questions about its safety profile and the adequacy of available data
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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed
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The molecule contains a cysteine-linked disulfide bridge that constrains the peptide into a cyclic conformation, an important feature for maintaining its signaling profile in biochemical and adipocyte-based assays
For that reason: Individuals with active cancer should avoid it