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Whilst current limited evidence does not suggest these medications directly worsen inflammatory bowel disease activity, their gastrointestinal side effectsincluding nausea, diarrhoea, and abdominal painmay overlap with Crohn's symptoms, complicating disease monitoring

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Though the research didnt directly compare Wegovy to metformin, the results suggest that the combination can be beneficial

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Prior chronic phenobarbital use, or prior phenobarbital loading: Be careful bout giving a loading dose to someone with a therapeutic level

The initial analysis revealed there is considerable uncertainty about the payback from the weight loss from GLP-1s