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These results suggest PI3K/Akt/mTOR signaling mediated the protection of GLP-1 on apoptosis in neurons (193)

Some patients have reported an increase in GERD symptoms, particularly during the initial phases of treatment

It may also appeal to patients who are newer to GLP-1 medications and want a well-established medication pathway before considering a more potent dual-action option

[10] In the SURMOUNT-1 trial, patients with obesity achieved average weight reductions of approximately 15-21% of body weight over 72 weeks, alongside improvements in cardiovascular risk factors including blood pressure and lipid profiles, though cardiovascular outcome benefits have not yet been established

Adherence rates have a significant impact on savings

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