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By reducing insulin resistance through weight loss and direct metabolic effects, it decreases the demand placed on beta cells
doi:10.1007/s00125-010-1937-z Lauffer L, Grieco A, Iakoubov R, Brubaker PL (2009) Metformin activates the AMPK pathway and improves survival of murine and human L-cells but does not directly increase GLP-1 secretion
About this article Cite this article Snchez-Garrido, M.A., Brandt, S.J., Clemmensen, C
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mechanism not yet experimentally confirmed in humans
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