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These are also the doses studied and approved for prevention of secondary cardiovascular events and metabolic dysfunction-associated steatotic liver disease (semaglutide) and for sleep apnea (tirzepatide)

In particular, SGLT2 inhibitors have revolutionized the management of diabetes, offering not only effective glycemic control but also significant cardiovascular and renal benefits demonstrated in adult studies

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Pregnant/lactating women Renal insufficiency: It may increase metabolic burden