For sertraline, studies have demonstrated its effectiveness in treating major depressive disorder, panic disorder, obsessive-compulsive disorder, and social anxiety disorder
That averages out to a 5% weight loss without even utilizing the maximally tolerated dose
Other active transport processes that mediate drug permeation and transport of essential nutrients via BBB include adsorptive transcytosis (for instance, transport of albumin), efflux transport, receptor-mediated transport (RMT) and carrier-mediated (through GLUT-1 protein) transport
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