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The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]
[1] [4] Cognitive Function and Metabolic Health Brain function and metabolic health depend heavily on energy availability
Key takeaway: These effects are dose-dependent and temporary
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Because levels are often quite low before a deficiency is recognized, it can take some time for serum concentrations to even out and symptoms to subside
Consultation is Key- Before considering vitamin B12 supplementation, its crucial to consult with a healthcare provider
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