In this study, the effects of L-carnitine administration on fatty liver of medaka ( Oryzias latipes ) were analysed, to check for disease improvement and metabolic changes
It was demonstrated, that metabolic disturbances in hypothalamic astrocytes, caused either by selective knock-out of insulin receptors or decreased generation of reactive oxygen species (ROS) modulated glucose transport via BBB and also led to modification in behavioral responses in experimental animals [95, 96]
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But the magnitude of effect in humans is modest compared to prescription GLP-1 medications
& Grundmark, B