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In the pivotal SURMOUNT-1 trial, cardiovascular adverse events occurred at similar or lower rates in tirzepatide-treated participants compared to placebo

A network meta-analysis comparing various GLP-1 receptor agonists (23 RCTs, N=11,545) demonstrated the superior efficacy of newer agents like semaglutide (2.4 mg) for weight loss compared to older options such as liraglutide (3.0 mg), although all GLP-1 RAs outperformed placebo

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GLP-3 (Retatrutide) is a synthetic research peptide used in preclinical and in-vitro literature

Understanding this helps you find the sweet spot that delivers benefits with minimal issues