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The role of substance P in stress and anxiety responses

It may promote abnormal angiogenesis (new blood-vessel growth), raising theoretical concerns in patients with cancer history

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A 30-60 minute gap between modalities prevents direct interference with blood flow

This actin-regulatory activity underlies TB-500's profound effects on cellular migration, with research showing the peptide increases cell migration rates 2-3 fold through enhanced formation of dynamic membrane protrusions and improved directional persistence