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The binding cleft of the PL8 family is located at the junction of these two domains, the N-terminal and c-terminal, where there are many positively charged amino acids that can bind to negatively charged HA substrates, and the binding cleft is located at the junction of the N-terminal and C-terminal domains, and through the dynamic inter-domain movement to open and close the substrate binding crack, and finally cleave hyaluronic acid [101, 102]

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