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GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]
Because insulin release is glucose-dependent, GLP-1 promotes insulin mainly when blood sugar is elevated, which is part of why the pathway is so attractive as a therapeutic target
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Some individuals may experience zinc depletion with long-term, high-dose supplementation
[1] [4] Patients with diabetes require monitoring for diabetic retinopathy, particularly if they have a history of retinopathy and rapid improvement in glycaemic control
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