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Lastly, genetic manipulation of antioxidant genes, such as Sod1 , Gpx 1 and Cat , in animal models alters susceptibility to alcohol-induced liver injury 28,29,30

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The third pathway is proline utilisation which occurs in mitochondria where proline is oxidised to pyrroline-5-carboxylate by mitochondrial proline dehydrogenase ( PUT1 ) which, in turn, is further oxidised to glutamate by 1-pyrroline-5-caboxylate dehydrogenase ( PUT2 ) 19