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Food and Drug Administration (FDA) for the management of type 2 diabetes in combination with exercise and a low-calorie diet

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Am J Physiol Endocrinol Metab (2011) 301(2):E31725.10.1152/ajpendo.00077.2011 133 FengRQianCLiuQJinYLiuLLiSet alExpression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes

In particular, transient interactions with residues at the base of the binding cavity correlate with enhanced kinetics for G protein activation, providing a rationale for differences in G protein-mediated signalling efficacy from distinct agonists

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