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Similar to humans, mice and rats with diabetes secrete more GIP in response to oral glucose

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The impact on postprandial glucose-lowering of altering the timing of metformin administration in relation to meals has been poorly characterised, although an open-label pilot study in five metformin-treated type 2 diabetes patients was indicative of improved glucose-lowering, enhanced GLP-1 secretion and slowed gastric emptying when metformin (1000 mg) was administered 30 min before the meal rather than with the meal [24]

Pyridoxine plays an important part in brain development and function

Karhunen LJ, Juvonen KR, Huotari A, Purhonen AK, Herzig KH

If your bowel habits shift but you still feel okay otherwise, its often just your body getting used to the medication