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Nat Rev Cancer , 2023, 23: 295316 Ruffell B, Chang-Strachan D, Chan V, Rosenbusch A, Ho CMT, Pryer N, Daniel D, Hwang ES, Rugo HS, Coussens LM

In other words, combining the two substances can make appetite changes and GI side effects harder to predict and potentially more uncomfortable

PAGln is closely associated with atherosclerotic cardiovascular disease (ASCVD) risk, primarily through mechanisms of enhanced platelet reactivity and thrombosis (126)

Patients should also be taught simple strategies to reduce side effects, such as drinking more fluids, increasing fiber slowly, and adjusting food choices when symptoms flare

For most patients without pre-existing cardiac conditions, a 57 bpm increase is clinically mild and well-tolerated

[7] The resulting half-life of active GLP-1 is approximately 2 minutes, which is however sufficient to activate GLP-1 receptors