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Neuroproteomic study of nitrated proteins in moderate traumatic brain injured rats treated with glutamyl cysteine ethyl ester administration post injury: insight into the role of glutathione elevation in nitrosative stress
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This aspect of the study focused on muscle responses to acetylcholine, a neurotransmitter involved in muscle contraction, and electrical field stimulation, a method used to mimic nerve impulses that trigger muscle contraction
He and his colleagues confirmed that the extra glutathione in the treated mice caused levels of RhoA to increase in their metastatic tumors
M1 microglia release neurotoxic and inflammatory factors such as IL-6, IL-1, and TNF-, contributing to neuronal damage and death, while M2 microglia secrete neurotrophic factors including BDNF, IL-4, and IL-10, fostering neuronal growth and protection (51)