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Para diseo experimental, las condiciones de exposicin (concentracin, vehculo, duracin) deben derivarse de la metodologa de los estudios primarios citados y ajustarse al modelo celular especfico del investigador

A dimer obtained by inserting a Cys-Cys linker between two units of KPV, (CKPV) 2 , inhibited tumor necrosis factor-alpha (TNF-) production by lipopolysaccharide (LPS)-stimulated human leukocytes with potency similar to the stable -MSH analog [Nle4-dPhe7]--MSH (NDP--MSH) and effectiveness greater than KPV

Singer et al., 2014

The peptide showed no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no immunogenicity with no anti-AOD-9604 antibodies detected