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Finally, tirzepatide was associated with significantly reduced occurrence of a composite kidney outcome comprising new-onset MA, 40% eGFR decline, end-stage renal disease and death due to kidney failure (HR 0.58, 95% CI 0.430.80) [49]
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Regarding organ outcomes, our review indicates that, in high-risk populations, GLP-1RAs are associated with a 12-15% relative risk reduction in MACE and favorable effects on composite renal endpoints
References Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED
