GLP-1s help the body release its own insulin but are not insulin
Beyond the synergistic effects on insulin secretion and synthesis, the double agonist therapy seems to strongly promote survival and differentiation of -cell (48) ( Figure 1 )
Wegovy mimics GLP-1 (the manufacturer reports it is 94% similar to the real thing) and produces similar results
Using them together would double-dose you with semaglutide, increasing the risk of side effects without providing additional benefits
Studies suggest that people who lose weight quickly, particularly with the aid of medications like GLP-1 receptor agonists, may have a higher likelihood of developing gallstones, which can cause severe abdominal pain and may require surgical intervention
Recently, vinca alkaloids have demonstrated to exert their neurotoxicity via activation of spinal cord glia (i.e., astrocytes and microglia), offering an option for the treatment of CIPN through pharmacological antagonism of this phenomenon