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A double-blind, placebo-controlled RCT of targeted oral naltrexone enrolled 120 sexual and gender minority men with mild to moderate AUD a targeted, biomarker-adjacent population and that study design reflected the ongoing tension in addiction pharmacotherapy between population specificity and label breadth
Trials indicate an average loss of 15% body weight over 68 weeks
GLP-1 RA use was heterogenous over time and depended on the index GLP-1 RA
Are Any Effects Permanent
These findings position Retatrutide as a critical research tool for investigators studying liver metabolism, fibrosis regression, and non-invasive biomarker development
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