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There isn't a lot of research on the health effects of periodic use, though other studies show weight regain after stopping GLP-1s is faster compared to other diets that focus on behavior changes

J Appl Physiol (1985) 110(3):774780

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However, Phase 2 trials are not always powered or designed to detect rare psychiatric adverse events, and longer-term Phase 3 data which would provide a more comprehensive safety profile had not been fully published at the time of writing