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Ongoing research includes: long-term pancreatic studies thyroid cancer surveillance 5-year cardiovascular follow-ups GI motility research safety monitoring for chronic users registries for severe GLP-1 complications FDA GLP-1 Warnings When to Call a Doctor Immediately Seek medical attention if you experience: severe abdominal pain persistent vomiting dehydration rapid weight loss inability to eat jaundice sharp back or flank pain little or no urine output These may indicate long-term GI damage, pancreatitis, or kidney injury
The histologic features of MIOM are nonspecific, but mild regenerative epithelial dysplasia, apoptotic figures in all epithelial layers, and a lichenoid inflammatory reaction may be observed in the connective tissue 7,47 as was seen in Case 1 and 4
The patient was conclusively diagnosed with MIOM, prompting the discontinuation of MTX and supplementation with 10mg folic acid/week
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Phosphorylation occurs on various cellular substrates on tyrosine residues including the IRS family and Src homology/collagen (SHC)-transforming family of proteins that mediate signals from the tyrosine kinases [132]
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