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These macrophages secrete pro-inflammatory cytokines such as IL-1 and TNF-, which not only promote intra-articular inflammation but also directly contribute to the degradation of the cartilage matrix (85, 137, 138)
When administered, it directly binds to toxic cyanide ions, forming harmless cyanocobalamin, which is then safely excreted in the urine
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10.1016/j.ecoenv.2019.109840 28 ElsedawiB
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