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The theoretical expectation, based on glucagon's metabolic effects, is that retatrutide may produce a better body composition outcome but this has not been definitively proven

Studies have shown that weight loss can dramatically lower the risk of complications associated with obesity

And that single word, "technically," deserves a closer look

10.1016/j.ijbiomac.2025.144198 84 LiangF.ZhengY.ZhaoC.LiL.HuY.WangC.et al (2025)

Meta-analyses and randomised controlled trials have consistently shown that semaglutide leads to significant weight reduction compared to placebo, with participants achieving 5-20% weight loss

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