In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions
Vitamin B12 also plays a vital role in maintaining the health of the nervous system by supporting the formation of myelinthe protective sheath around nerves that ensures fast, efficient signal transmission
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These anecdotal reports come with obvious limitations
Simultaneously, the GHK-Cu complex has been shown in vitro to interact with components of the TGF- superfamily signaling axis and to up-regulate expression of anti-apoptotic and extracellular matrix (ECM) remodeling genes, including those encoding fibronectin, collagen I, and various matrix metalloproteinases (MMPs) as well as their inhibitors (TIMPs)