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Laboratory studies have investigated MOTS-c for roles in cellular metabolism, AMPK signalling, and metabolic stress responses
Research has focused on its facilitation of synapse formation via HGF/Met receptor signalling, with investigations suggesting neurotrophic potency orders of magnitude greater than BDNF in dendritic branching assays
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NRF2 reprograms cellular metabolism to funnel metabolic intermediates into antioxidant pathways While NRF2 regulates the expression of antioxidant and NADPH-generating enzymes, metabolic intermediates are required to support these pathways
Finally, we observed that activation of astrocytes with consequent endogenous production of lactate is associated with neuroprotection
Your unique genetics determine how well your body makes and uses glutathione and how you respond to diet changes
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