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Retatrutide works as a powerful triple-agonist, meaning it works on on three key hormone receptors: The human glucagon receptor (GCGR) The glucose-dependent polypeptide receptor (GIP receptor) The glucagon-like peptide-1 receptor (GLP-1) This unique receptor profile allows retatrutide to effectively: Regulate appetite, feelings of fullness, and gastric emptying Regulate metabolism Regulate blood sugar levels The activation of the GIP, GLP-1, and GCG receptors simultaneously by retatrutide leads to better weight loss and cardiometabolic benefits compared to targeting a single receptor

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In the technical scheme of the invention, the condensing agent adopted in the coupling in the step (3) and the step (5) comprises DIC + A or B + A + C, wherein A is HOBt or HOAt, B is HBTU, HATU or PyBOP, and C is DIEA or TMP or DMAP