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The differentially expressed genes were filtered using the condition Fold change 2 or 2 and the genes that fulfilled that condition were listed (Supplementary Data 13)

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Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease

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Some individuals notice improved sleep quality, reduced morning stiffness, or slightly better tolerance for activities that previously caused discomfort

However, navigating the information online can be confusingclaims often outpace the science, and safety recommendations vary widely