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The nausea mechanism with semaglutide involves delayed gastric emptying and central GLP-1 receptor activation in the brainstem

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While current commercial products primarily utilize subcutaneous injection, researchers are developing oral tablets with permeation enhancers, mucoadhesive buccal films, intranasal sprays, and even transdermal patch systems

Its osmotic effect draws water into the intestines, softening stool and stimulating motility