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Preclinical Combination Data Valdecantos et al
Safety monitoring: More frequent blood pressure checks (peptides may affect pressure in vulnerable elderly), kidney function monitoring if long-term use, medication interaction review with physician or pharmacist, close observation for confusion or side effects
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In clinical practice, even straightforward injectable treatments benefit from sterile technique, proper patient evaluation, and staff trained to recognize and manage adverse reactions
Most patients experienced either very mild or no noticeable reaction
In a phase 2 clinical trial for obesity, 26 weeks of efinopegdutide (doses 5 to 10mg) resulted in up to 11.8% WL in people with obesity (without diabetes) compared to 7.5% WL with liraglutide 3 mg and 1.8% WL with placebo [77, 78]
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