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1 Despite remarkable advances in targeted therapies, immunotherapies, and combination regimens, a significant proportion of patients experience either intrinsic resistance, where tumors fail to respond from the outset, or acquired resistance, which emerges after an initial therapeutic response

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(3) Clinical Validation: Large-scale, well-designed clinical trials are urgently needed to evaluate the safety and efficacy of ferroptosis-targeting strategies (e.g., deferiprone, novel inhibitors) in COPD patients, ideally using biomarker-driven patient selection (e.g., based on MDA, 4-HNE, or GPX4 activity levels)

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