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[PMID: 20623149] 16
Catalytic organometallic anticancer complexes
The induction of ICD in tumor cells during PDT treatment is primarily attributed to the generation of intracellular ROS under NIR irradiation, which occurs after photosensitizer aggregation in the ER, causing disruptions in ER homeostasis, elevating calcium levels in the ER, and losing SERCA2 function
Hydroxyl radicals are extremely reactive and may cause extensive damage to cellular components
Molecular signaling investigations involving copper-dependent peptide communication pathways within cellular research systems Peptidemetal binding interaction studies examining the behavior of copperpeptide complexes in biochemical environments Intracellular signaling cascade analysis within experimental models exploring peptide-mediated regulatory mechanisms Stability profiling and structural integrity evaluation following peptide reconstitution and controlled storage conditions Comparative investigations analyzing copper-binding peptides within broader peptide signaling and molecular communication research frameworks Analytical benchmarking within peptide research workflows utilizing validated laboratory reference materials and chromatographic verification methods All referenced applications remain strictly confined to laboratory-based investigation and non-clinical experimental use
Westermark P, Andersson A, Westermark GT
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