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For pH optimization, fermentations were conducted in a 2.5 L bioreactor containing 1 L of YCK50D medium under controlled pH conditions

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37 , 38 , 39 Partial indirect support for this is that G6PD deficiency in Sardinia is more common at sea level compared to higher elevations, and this also parallels the endemicity of malaria

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S., Spiering, B