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Additionally, intracerebroventricularly (ICV) injected LUXendin 645 hardly reaches the MCL and GCL of the OB (Supplementary Fig

This activation triggers several physiological responses: it slows gastric emptying (an effect that may attenuate over time with continued use), which initially prolongs the sensation of fullness after meals

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However, unregulated or high-dose injections can pose risks such as allergic reactions or infection

Exenatide mimics natural hormones called incretins which stimulate an increase release of insulin after meals helping lower blood glucose levels