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To improve the selectivity, in this work, we design and synthesize a malononitrile-functionalized TPE derivative, TPE-DCV, which can undergo addition reaction with thiol group to the alkene bond, leading to the change in its fluorescence in the system (Figure 1)

Injectables may be reserved for acute, hospital-based situations or severe oxidative stressbut are not ideal for long-term outpatient management

2007, Corrales FJ, Ruiz F, Mato J: In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver

GSH was then measured according to kit specifications (Cayman Chemical, Ann Arbor, MI, USA, 703002)