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Limited human evidence: Human studies have mainly evaluated safety and metabolic markers

The main limitations of these studies were the high heterogeneity among the included studies and the incomplete reporting of steroid exposure, including dosage and duration

Silver Spring, MD: US Food and Drug Administration

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Data from the European LEOSS registry as well as other data show an additive effect of obesity, diabetes, and hypertension on the risk of mortality, which is higher in young and middle-aged patients (1855 years)

But for medications at the price point of GLP-1 drugs, they're a normal part of the process