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Methods: A PRISMA-guided systematic review was conducted using PubMed and MEDLINE databases with search terms glutathione AND topical AND skin OR dermatology. From 446 articles, only clinical trials on topical glutathione were included, excluding reviews, animal studies, and research on oral or intravenous glutathione

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Oral glutathione at standard doses (250500 mg/day) has been used in studies lasting 46 months without significant adverse effects

Apoptosis in pyrogallol-treated Calu-6 cells is correlated with the changes of intracellular GSH levels rather than ROS levels

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Arthur JR (2000) The glutathione peroxidases