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The natural feedback loop, where GH rising in the blood signals back to suppress further release (a process called negative feedback), stays largely intact
MagnsdttirSRavcheevDde Crcy-LagardVThieleI
In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes
Cell 177:1522-1535.e14
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