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Key benefits for analysis of retatrutide using the ZenoTOF 7600 system Sensitive quantitation of retatrutide: Achieve 2.5 ng/mL LLOQ for the quantitation of retatrutide in human plasma Simple and fast sample preparation: Utilize a simple protein precipitation and achieve an average 89.6% recovery for the quantitation of retatrutide in human plasma Robust analytical performance: Achieve highly reproducible quantitative performance with %CV 0.996 was reached, showing excellent linearity across a wide calibration range

12-week community planning example Phase Observation phase Weeks 14 Daily amount 300 mcg Phase total 8.4 mg Phase Later phase Weeks 512 Daily amount 500 mcg Phase total 28 mg Phase Full cycle Weeks 112 Daily amount Mixed schedule Phase total 36.4 mg METAOD005 also lasted 12 weeks, but it tested oral doses from 1 to 30 mg per day