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In rare situations, there are worries about possible thyroid tumors

Pathogenesis The hyperpigmentation observed in CALMs is due to increased melanogenesis and an increased melanin content within keratinocytes

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In the SURMOUNT-1 trial, Mounjaro helped people lose up to 22.5% of their starting body weight at 72 weeks

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Elegant studies of this type have been done for example by Leshan and colleagues to show that only a subpopulation of VTA dopamine neurons projecting specifically to the amygdala but not the NAc is activated by leptin (Leshan et al., Concluding remarks Behavioral feeding responses are evolutionarily conserved and necessary for survival