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The leucine threshold is based on research by Layman and colleagues showing that approximately 2.5 g of leucine per meal is needed to maximally stimulate muscle protein synthesis in adults

Some specialty pharmacies compound at 1 mg/mL for patients who need very low starting doses, and others go as high as 10 or 12.5 mg/mL for patients on higher maintenance doses who want to inject smaller volumes

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Any patient who experiences persistent vomiting, severe abdominal pain, or jaundice should be evaluated promptly for pancreatitis or gallbladder disease, both of which occur at modestly elevated rates with GLP-1 class drugs [5]