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Nausea affects 80 to 90 percent of users but typically resolves after 3 to 5 days

10.1097/00004850-199100610-00005 46 HiraiK.YamashitaH.TomoshigeS.MishimaY.NiwaT.OhganeK.et al (2022)

Berberine's effects on mitochondrial function and metabolic efficiency could theoretically complement this

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However, there are a few other kinds of supplements that improve common complaints also addressed by nootropics

For example, in response to acute stress exposure, mitochondria respond dynamically to cues from stress-signaling pathways enacted by glucocorticoids [192], to meet increased energy demands [202]