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Some individuals may be relative "non-responders" at lower doses but achieve satisfactory results with dose escalation
The positive regulation of pro-inflammatory macrophage activity appears to be dependent on activation of STAT1, whereas the increased anti-inflammatory activation is driven by ER-mediated phosphorylation and activation of STAT3 and interference with p65 subunit binding to the NF-B complex (158161)
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doi: 10.2337/dc13-2760 219 MarreMShawJBrndleMBebakarWMKamaruddinNAStrandJet al
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