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Repeated semaglutide injection data were analyzed using a three-way repeated-measures linear mixed model in SPSS (version 29.0.1.0), as Prism does not support three-way ANOVAs with more than two levels across multiple factors

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The leading explanation, supported by preclinical work, is that glucagon-receptor agonism drives degradation of PCSK9, which in turn increases hepatic LDL-receptor availability and clears circulating LDL

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