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(Source 1) Suboptimal and deficient glutathione levels are associated with aging and an increased risk for chronic diseases, including: Mitochondrial dysfunction Neurodegenerative disease, including Alzheimers and Parkinsons disease Cancer Chronic liver disease Metabolic disease, including diabetes and hypertension Cardiovascular disease Pulmonary Infertility Autoimmune diseases, including lupus and multiple sclerosis Mental health disorders Cystic fibrosis (Source 1, 2) A viral illness, including SARS-CoV-2, the virus that causes Covid-19, can also cause glutathione deficiency

Studies have shown that decreased HPPD expression under disease conditions is linked to poor overall survival, highlighting its potential clinical relevance as a prognostic marker in HCC patients

According to the American Society for Dermatologic Surgery, the FDA proposed an OTC ban way back in 2006, recommending more studies by the National Toxicology Program (NTP) due to as-yet-unproven concerns that it may cause cancer, as well as concerns over ochronosisskin darkening (in other words, the opposite of what most hydroquinone users are going for)

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